Fluocinonide (Lidex, Lyderm, Metosyn, Topsyn, Fluocinolide, Vanos, Lonide) is a potent glucocorticoid/corticosteroid that has been approved for use as a topical anti-inflammatory drug for the treatment of skin disorders such as seborrhoeic dermatitis and eczema.
Mirogabalin besylate (DS-5565) is a potent, selective and orally bioavailable α2δ-1 ligand under development for treating pain associated with diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia.
ML218 (CID-45115620; ML-218; CID45115620) is a novel, potent and selective T-Type Ca(2+) (Ca(v)3.1, Ca(v)3.2, Ca(v)3.3) inhibitor (Ca(v)3.2, IC(50) = 150 nM in Ca(2+) flux; Ca(v)3.2 IC(50) = 310 nM and Ca(v)3.3 IC(50) = 270 nM, respectively in patch clamp electrophysiology) with good DMPK properties, it displayed acceptable in vivo rat PK and excellent brain levels.
(R)-(+)-Bay-K-8644, the R-isomer of Bay-K-8644, is a novel and potent a calcium channel inhibitor/blocker that inhibits Ba2+ currents (IBa) (IC50=975 nM).
Desonide (Budesonide acetonide), a non-fluorinated corticosteroid approved as anti-inflammatory drug, is a low potency topically used corticosteroid with anti-inflammatory activities.
Cortisone acetate (NSC49420; NSC-49420; Cortone acetate; Cortisyl; Incortin), a steroid hormone, is an acetate ester prodrug form of cortisone with glucocoriticoid and mineral corticoid activities.
Lercanidipine HCl (REC-15-237, Lercadip, Lerdip, Zanidip) is a 3rd generation and lipophilic CCB (calcium channel blocker) of the dihydropyridine class and a medication used to treat high blood pressure, with long lasting antihypertensive action and reno-protective effect.
Levamlodipine besylate, the besylate salt of Levamlodipine which is the S-isomer and impurity of Amlodipine (Amlodis; Amlor, Coroval; Lipinox; Norvasc; Amvaz), is an anti-hypertensive agent of the dihydropyridine (DHP) class and can be used for lowering blood pressure.
Prednisone (also known as Dehydrocortisone; trade names: Adasone; Deltasone, Liquid Pred, Orasone, among others) is an approved glucocorticoid medication mostly used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases.
O4I2 (O-4I2; O4I-2; O-4I 2; O-4I2; O-4I-2; O4-I-2) is a novel and potent inducer of Oct3/4 (POU5F1 and Oct4).