EN6 is a small-molecule in vivo activator of autophagy that covalently targets cysteine 277 in the ATP6V1A subunit of the lysosomal the vacuolar H+ ATPase (v-ATPase).

Fasudil (also known as HA-1077) is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM in cell-free assays, respectively, it is used as a vasodilator for the treatment of cerebral vasospasm, which is often due to subarachnoid hemorrhage, as well […]

Vitexin is a novel and potent apigenin flavone glucoside found in plants i.e.

Syringin is a novel and potent phenylpropanoid glycoside.

Lanatoside C is a novel and potent anticancer agent.

Amiodarone (NSC 85442) is an antiarrhythmic agent that acts as a sodium/potassium-ATPase inhibitor and an autophagy activator that is used to treat various types of cardiac dysrhythmias.

IITZ-01 is a novel and potent lysosomotropic autophagy inhibitor which has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo.

KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM .

S29434 (NMDPEF) is a potent, competitive, selective and cell membrane-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1.

CA-77.1 is a novel,potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator.