Lys-SMCC-DM1 TFA

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$4450	Check With Us
200mg	$6675	Check With Us
500mg	$11250	Check With Us

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Cat #: V33339 CAS #: 1281816-04-3 Purity ≥ 98%

Description: Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is an FDA approved HER2-targeting ADC (antibody-drug conjugate). Lys-SMCC-DM1 (also known as Lys-Nε-MCC-DM1) is a drug-linker conjugate in which DM1 acts as an inhibitor of tubulin polymerization. T-DM1 is a human epidermal growth factor receptor 2 (HER2)-targeting ADC for cancer treatment.

References: [1]. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	1103.71
Molecular Formula	C53H75ClN6O15S
CAS No.	1281816-04-3
SMILES Code	C[C@]1([C@@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([C@H](C)N(C)C(CCS[C@@H](CC4=O)C(N4C[C@@H]5CC[C@@H](C(NCCCC[C@H](N)C(O)=O)=O)CC5)=O)=O)=O)[C@H]([C@@H]([C@](OC6=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N6)O)C)O
Synonyms	Lys-Nε-MCC-DM1;

Protocol	In Vitro	Lys-SMCC-DM1 具有低渗透性。 Lys-SMCC-DM1 在 KPL-4 和 MDA-MB-468 细胞中表现出细胞毒性，IC50 分别为 24.8 nM 和 40.5 nM。 Lys-SMCC-DM1 (200 μM) 抑制 MDCKII/SLC46A3 dC 细胞中 SLC46A3 介导的雌酮 3-硫酸盐摄取。

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.9060 mL	4.5302 mL	9.0604 mL	18.1207 mL
5mM	0.1812 mL	0.9060 mL	1.8121 mL	3.6241 mL
10mM	0.0906 mL	0.4530 mL	0.9060 mL	1.8121 mL
20mM	0.0453 mL	0.2265 mL	0.4530 mL	0.9060 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.