Docetaxel (RP 56976)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$245	In Stock
5g	$290	In Stock
10g	$566	In Stock

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Cat #: V1604 CAS #: 114977-28-5 Purity ≥ 98%

Description: Docetaxel (formerly known as RP56976; NSC628503; RP-56976; NSC-628503; Taxotere), a semisynthetic analog of paclitaxel and approved anticancer drug, is a mitotic inhibitor and tubulin inhibitor that inhibits the depolymerization of microtubules by binding to and stabilizing microtubules.

References: Attia RT, et al. The chemomodulatory effects of glufosfamide on docetaxel cytotoxicity in prostate cancer cells. PeerJ. 2016 Jun 29;4:e2168.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	807.88
Molecular Formula	C43H53NO14
CAS No.	114977-28-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (123.8 mM)r
	Water:<1 mg/mLr
	Ethanol: 53 mg/mL (65.6 mM)
Solubility In Vivo	5% DMSO+30% PEG 300+5% Tween 80+ddH2O: 2 mg/mL
Synonyms	RP56976; NSC 628503; RP-56976; NSC628503; RP 56976; NSC-628503; Docetaxel hydrate, Trade name: Taxotere. Chemical Name: (2aR,4S,4aS,6R,9S,11S,12S,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate. SMILES Code: O=C(O[C@@H](C1[C@@]2(C)[C@@H](O)C[C@@]3([H])OC[C@]31OC(C)=O)[C@]4(O)C[C@H](OC([C@H](O)[C@@H](NC(OC(C)(C)C)=O)C5=CC=CC=C5)=O)C(C)=C(C4(C)C)[C@@H](O)C2=O)C6=CC=CC=C6

Protocol	In Vitro	Single and combined treatments of Docetaxel (RP-56976) and glucosamide (GLU) affect cell viability in a dose-dependent manner. IC of GLU in PC-3 and LNCaP cells5070±4 μM and 86.8±8 μM, respectively. Meanwhile, in PC-3 and LNCaP cells, Docetaxel's IC alone was used50 3.08±0.4 nM and 1.46±0.2 nM GLU were treated in combination with Docetaxel for synergistic cytotoxicity, PC-3 and LNCaP cell ICs, respectively50 Values are reduced to 2.7±0.1 nM and 0.75±0.3 nM, respectively

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.2378 mL	6.1890 mL	12.3781 mL	24.7562 mL
5mM	0.2476 mL	1.2378 mL	2.4756 mL	4.9512 mL
10mM	0.1238 mL	0.6189 mL	1.2378 mL	2.4756 mL
20mM	0.0619 mL	0.3095 mL	0.6189 mL	1.2378 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.