ICG-001
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | In Stock |
| 500mg | $1250 | In Stock |
| 1g | $1875 | In Stock |
: Cat #: V1350 CAS #: 780757-88-2 Purity ≥ 98%
Description: ICG-001 (ICG001; ICG 001) is a novel and potent inhibitor of β-catenin/TCF mediated transcription.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 548.63 |
|---|---|
| Molecular Formula | C33H32N4O4 |
| CAS No. | 780757-88-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (182.3 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 10 mg/mL (18.2 mM) | |
| Synonyms | ICG-001; ICG 001; ICG001 |
| Protocol | In Vitro | ICG-001 (25 μM) treatment reduces homeostatic levels of survival and cyclin D480 RNA and protein in SW1 cells, both of which can be upregulated by β-catenin. ICG-001 selectively induces apoptosis in transformed cells rather than normal colon cells and reduces in vitro growth of colon cancer cells |
|---|---|---|
| In Vivo | After 001 weeks of administration of the water-soluble analogue of ICG-9, the formation of colon and small intestinal polyps was reduced by 42%, which was as effective as the nonsteroidal anti-inflammatory drug MK-231, which has consistently shown efficacy in this model. ICG-001 (150 mg/kg, intravenously) showed a significant reduction in tumor volume with no death or weight loss over 620 days of treatment in the SW19 nude mouse tumor regression xenograft model |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8227 mL | 9.1136 mL | 18.2272 mL | 36.4544 mL |
| 5mM | 0.3645 mL | 1.8227 mL | 3.6454 mL | 7.2909 mL |
| 10mM | 0.1823 mL | 0.9114 mL | 1.8227 mL | 3.6454 mL |
| 20mM | 0.0911 mL | 0.4557 mL | 0.9114 mL | 1.8227 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.