Lys-SMCC-DM1 TFA

This product is for research use only, not for human use. We do not sell to patients.

Lys-SMCC-DM1 TFA
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Size Price Stock
100mg$4450Check With Us
200mg$6675Check With Us
500mg$11250Check With Us

Cat #: V33339 CAS #: 1281816-04-3 Purity ≥ 98%

Description: Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is an FDA approved HER2-targeting ADC (antibody-drug conjugate). Lys-SMCC-DM1 (also known as Lys-Nε-MCC-DM1) is a drug-linker conjugate in which DM1 acts as an inhibitor of tubulin polymerization. T-DM1 is a human epidermal growth factor receptor 2 (HER2)-targeting ADC for cancer treatment.

References: [1]. Ogitani Y, et al. Bystander killing effect of DS-8201a, a novel anti-human epidermal growth factor receptor 2 antibody-drug conjugate, in tumors with human epidermal growth factor receptor 2 heterogeneity. Cancer Sci. 2016 Jul;107(7):1039-46.

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Molecular Weight (MW)1103.71
Molecular FormulaC53H75ClN6O15S
CAS No.1281816-04-3
SMILES CodeC[C@]1([C@@](CC(N(C(C=C2C=C3OC)=C3Cl)C)=O)([H])OC([C@H](C)N(C)C(CCS[C@@H](CC4=O)C(N4C[C@@H]5CC[C@@H](C(NCCCC[C@H](N)C(O)=O)=O)CC5)=O)=O)=O)[C@H]([C@@H]([C@](OC6=O)([H])C[C@]([C@](/C=C/C=C(C)/C2)([H])OC)(N6)O)C)O
SynonymsLys-Nε-MCC-DM1;
ProtocolIn VitroLys-SMCC-DM1 具有低渗透性。 Lys-SMCC-DM1 在 KPL-4 和 MDA-MB-468 细胞中表现出细胞毒性,IC50 分别为 24.8 nM 和 40.5 nM。 Lys-SMCC-DM1 (200 μM) 抑制 MDCKII/SLC46A3 dC 细胞中 SLC46A3 介导的雌酮 3-硫酸盐摄取。
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM0.9060 mL4.5302 mL9.0604 mL18.1207 mL
5mM0.1812 mL0.9060 mL1.8121 mL3.6241 mL
10mM0.0906 mL0.4530 mL0.9060 mL1.8121 mL
20mM0.0453 mL0.2265 mL0.4530 mL0.9060 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

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Concentration(final)
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.