HS1371
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $750 | In Stock |
| 250mg | $1150 | In Stock |
| 500mg | $1725 | In Stock |
: Cat #: V3954 CAS #: 2158197-70-5 Purity ≥ 98%
Description: HS-1371 is a novel, potent and ATP-competitive RIP3 (receptor-interacting protein kinase 3) inhibitor that is identified by the extensive screening of chemical libraries focused on kinases.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 384.48 |
|---|---|
| Molecular Formula | C24H24N4O |
| CAS No. | 2158197-70-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | CC1=CC=C(OC2=CC=NC3=CC(C4=CN(C5CCNCC5)N=C4)=CC=C23)C=C1 |
| Synonyms | HS 1371; HS1371; HS-1371; |
| Protocol | In Vitro | HS-1371 (0.1, 1, 5, 10 μM, 24 h) rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death. (In Vitro) HS-1371 directly binds to RIP3 in an ATP-competitive and time-independent manner. HS-1371 has an inhibitory effect on RIP3 kinase activity in various cell lines. HS-1371 (0.1, 1, 5, 10, 20 μM, 9 h) can block RIP3 S227 phosphorylation. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6009 mL | 13.0046 mL | 26.0092 mL | 52.0183 mL |
| 5mM | 0.5202 mL | 2.6009 mL | 5.2018 mL | 10.4037 mL |
| 10mM | 0.2601 mL | 1.3005 mL | 2.6009 mL | 5.2018 mL |
| 20mM | 0.1300 mL | 0.6502 mL | 1.3005 mL | 2.6009 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.