GSK-872 hydrochloride (GSK’872; GSK2399872A; GSK872; GSK-872) is a novel, potent and selective RIPK3 (receptor interacting protein kinase-3) inhibitor with anticancer and anti-inflammatory effects.
WEHI-345 (WEHI345) is a novel, potent and selective RIPK2 inhibitor with therapeutic potential to treat NOD-driven inflammatory diseases.
GSK2982772 (GSK-2982772; GSK772) is a potent, selective, oral and ATP competitive inhibitor of RIP1 (receptor Interacting Protein 1) with the potential for the treatment of inflammatory diseases.
GSK-843 (GSK’843) is a novel and potent inhibitot of receptor-interacting protein kinase 3 (RIP3 or RIPK3) with anti-inflammatory effects.
GSK-963 (also known as GSK’963 or GSK963), is a potent and selective RIP1 kinase inhibitor.
GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM .
Necrostatin 2 S-isomer is the S-enantiomer of Necrostatin 2 (also known as Necrostatin-2, Necrostatin-2 racemate, (±)-Necrostatin-2, 7-Cl-O-Nec-1 and Nec-1s) which is a potent necroptosis inhibitor with EC50 of 50 nM.
Necrostatin-2, formerly known as (±)-Necrostatin-2, 7-Cl-O-Nec-1 and Nec-1s, is a racemic mixture of Necrostatin-2 that inhibits receptor-interacting protein kinase 1 (RIPK1) autophosphorylation.
GSK2983559 free acid (compound 3) is a potent, specific and oral bioactive receptor interacting protein 2 (RIP2) kinase inhibitor, showing excellent activity in blocking many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.
GSK’481 is a novel, potent and selective inhibitor of RIP1 (receptor interacting protein 1) WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells.