YKL-06-061
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $650 | Check With Us |
| 250mg | $1150 | Check With Us |
| 500mg | $1725 | Check With Us |
: Cat #: V28380 CAS #: 2172617-15-9 Purity ≥ 99%
Description: YKL-06-061 (YKL06-061) is a novel and potent SIK (salt-inducible kinase) inhibitor (IC50: 6.56 nM/1.77 nM/20.5 nM (SIK1/2/3)) with the potential to be used as a dermatologic drug impacting UV protection and skin cancer risk.
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| Molecular Weight (MW) | 527.66 |
|---|---|
| Molecular Formula | C30H37N7O2 |
| CAS No. | 2172617-15-9 |
| SMILES Code | O=C1N(C2CCC2)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6C |
| Synonyms | YKL-06-061; YKL06-061; YKL 06-061; YKL-06061; YKL06061; YKL 06061 |
| Protocol | In Vitro | YKL 06-061 yields a dose-dependent increase in MITF mRNA expression. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8952 mL | 9.4758 mL | 18.9516 mL | 37.9032 mL |
| 5mM | 0.3790 mL | 1.8952 mL | 3.7903 mL | 7.5806 mL |
| 10mM | 0.1895 mL | 0.9476 mL | 1.8952 mL | 3.7903 mL |
| 20mM | 0.0948 mL | 0.4738 mL | 0.9476 mL | 1.8952 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.