YK-4-279
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | Check With Us |
| 500mg | $750 | Check With Us |
| 1g | $1125 | Check With Us |
: Cat #: V1436 CAS #: 1037184-44-3 Purity ≥ 98%
Description: YK-4-279 (YK-4279; YK4279; YK4-279; YK 4-279) is a potent inhibitor of EWS-FLI1 binding to RNA helicase A (RHA) with potential anticancer activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 366.20 |
|---|---|
| Molecular Formula | C17H13Cl2NO4 |
| CAS No. | 1037184-44-3 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 73 mg/mL (199.3 mM)rr |
| Water: <1 mg/mLrr | |
| Ethanol: 51 mg/mL (139.3 mM) | |
| Synonyms | YK-4-279; YK-4279; YK4279; YK4-279; YK 4-279; YK 4279. |
| Protocol | In Vitro | YK-4-279 (3-30 µM; overight) dissociates EWS-FLI1 from RHA in Ewing’s sarcoma family tumor (ESFT) cells |
|---|---|---|
| In Vivo | YK-4-279 (1.5 mg; i.p. once) inhibited ESFT tumor growth | |
| Animal model | Beige mice with orthotopic ESFT and ESFT xenografts | |
| Dosages | 1.5 mg | |
| Administration | Intraperitoneal injection; 1.5 mg once |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7307 mL | 13.6537 mL | 27.3075 mL | 54.6150 mL |
| 5mM | 0.5461 mL | 2.7307 mL | 5.4615 mL | 10.9230 mL |
| 10mM | 0.2731 mL | 1.3654 mL | 2.7307 mL | 5.4615 mL |
| 20mM | 0.1365 mL | 0.6827 mL | 1.3654 mL | 2.7307 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.