VU0134992
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $1050 | Check With Us |
| 100mg | $1599 | Check With Us |
| 200mg | $2400 | Check With Us |
: Cat #: V28072 CAS #: 755002-90-5 Purity ≥ 99%
Description: VU0134992 is a selective Kir4.1 potassium channel pore blocker.
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| Molecular Weight (MW) | 411.38 |
|---|---|
| Molecular Formula | C20H31BrN2O2 |
| CAS No. | 755002-90-5 |
| Synonyms | VU-992; VU 992; VU992; VU-0134992; VU 0134992; VU0134992 |
| Protocol | In Vitro | VU0134992 is greater than 30-fold selective for Kir4.1 over Kir1.1, Kir2.1, and Kir2.2, is weakly active toward Kir2.3, Kir6.2/SUR1, and Kir7.1, and is equally active toward Kir3.1/3.2, Kir3.1/3.4, and Kir4.2. |
|---|---|---|
| In Vivo | VU0134992 (50-100 mg/kg; oral gavage) statistically significantly increased urinary Na+ as well as K+ excretion | |
| Animal model | Male Sprague-Dawley rats (250-300 g) | |
| Dosages | 50 and 100 mg/kg | |
| Administration | Oral gavage |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4308 mL | 12.1542 mL | 24.3084 mL | 48.6169 mL |
| 5mM | 0.4862 mL | 2.4308 mL | 4.8617 mL | 9.7234 mL |
| 10mM | 0.2431 mL | 1.2154 mL | 2.4308 mL | 4.8617 mL |
| 20mM | 0.1215 mL | 0.6077 mL | 1.2154 mL | 2.4308 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.