Vinorelbine ditartrate (KW-2307)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$445	Check With Us
1g	$700	Check With Us
5g	$1900	Check With Us

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Cat #: V1615 CAS #: 125317-39-7 Purity ≥ 98%

Description: Vinorelbine ditartrate (KW-2307; KW2307; Navelbine, Biovelbin, Eunades; Nor-5'-anhydrovinblastine), the ditartrate salt of vinorelbine which is an antimitotic agent, is a tubulin inhibitor and microtubule stablizer approved for cancer treatment.

References: Ngan VK, et al. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol. 2001 Jul;60(1):225-32.

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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	1079.11
Molecular Formula	C45H54N4O8.2C4H6O6
CAS No.	125317-39-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (92.7 mM)r
	Water: 100 mg/mL (92.7 mM)r
	Ethanol: 100 mg/mL (92.7 mM)
Synonyms	KW2307, Nor-5'-anhydrovinblastine ditartrate, vinorelbine tartrate, KW-2307, KW 2307, Navelbine, Biovelbin, Eunades

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.9267 mL	4.6334 mL	9.2669 mL	18.5338 mL
5mM	0.1853 mL	0.9267 mL	1.8534 mL	3.7068 mL
10mM	0.0927 mL	0.4633 mL	0.9267 mL	1.8534 mL
20mM	0.0463 mL	0.2317 mL	0.4633 mL	0.9267 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.