Vinflunine ditartrate (BMS 710485)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $920 | To Be Confirmed |
| 250mg | $1600 | To Be Confirmed |
| 500mg | $2400 | To Be Confirmed |
: Cat #: V3769 CAS #: 194468-36-5 Purity ≥ 99%
Description: Vinflunine ditartrate (F 12158, BMS 710485) is a new analog of the vinca alkaloid vinorelbine that is bi-fluorinated strucuturally.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 1079.11 |
|---|---|
| Molecular Formula | C53H66F2N4O20 |
| CAS No. | 194468-36-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (103.4 mM)r |
| Water: 66 mg/mL (68.3 mM)r | |
| Ethanol: 11 mg/mL (11.4 mM) | |
| Solubility In Vivo | Saline: 30 mg/mL |
| Synonyms | Vinflunine; Vinflunine tartrate; vinflunine ditartrate; F 12158, F12158, F-12158, BMS 710485, BMS710485, BMS-710485 |
| Protocol | In Vitro | Vinflunine (0.01-10 μM; 45 min) induces a rapid change in endothelial cell shape: cells retracted and assumed a rounded morphology |
|---|---|---|
| In Vivo | Vinflunine (0.63-5 mg/kg; i.v. before and 2 d after Matrigel implantation) inhibits the bFGF-induced angiogenic response in mice in a dose-dependent manner | |
| Animal model | Female athymic nude mice (BALB/c/Ola/Hsd-nu) were implanted LS174T cells | |
| Dosages | 0.08, 0.16, 1.25, 5, 10, 20 mg/kg | |
| Administration | I.v. on days 4, 7, 11, 14, 18 and 21 after tumour cell implantation |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 0.9267 mL | 4.6334 mL | 9.2669 mL | 18.5338 mL |
| 5mM | 0.1853 mL | 0.9267 mL | 1.8534 mL | 3.7068 mL |
| 10mM | 0.0927 mL | 0.4633 mL | 0.9267 mL | 1.8534 mL |
| 20mM | 0.0463 mL | 0.2317 mL | 0.4633 mL | 0.9267 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.