Crolibulin, formerly known as EPC2407 and crinobulin, is a small molecule tubulin polymerization inhibitor with potential antineoplastic activity.
SSE15206 is a mitotic inhibitor, specifically, a microtubule depolymerizing agent that can overcome multidrug resistance.
HA15 (HA-15) is an inhibitor of chaperone BiP (Binding immunoglobulin protein, GRP78) with anticancer activity.
Colchicine (Colchicina; Condylon; Colsaloid; Colchicinum) is a mitotic/tubulin inhibitor that inhibits microtubule polymerization (also called microtubule disrupting agent or tubulin inhibitor) with potential anticancer and anti-inflammatory effects.
Taltobulin (HTI-286; SPA-110), an analog of the natural tripeptide hemiasterlin, is a tubulin inhibitor with anticancer activity.
7-epi-Taxol, the epimer of taxol (paclitaxel), is a major and active metabolite of taxol isolated from Taxus brevifolia with comparable anticancr/antitubulin activity to that of paclitaxek/taxol.
Mc-MMAE is a novel protective group for MMAE [(maleimidocaproyl)-conjugated monomethyl auristatin E], which is a highly potent mitotic/tubulin inhibitor, and is a toxin payload/warhead in antibody drug conjugate (ADC).
Myoseverin is an inducer of the reversible fission of multinucleated myotubes into mononucleated fragments, affecting the expression of a variety of growth factor, immunomodulatory, extracellular matrix-remodeling, and stress response genes, consistent with the activation of pathways involved in wound healing and tissue regeneration.
Ombrabulin HCl (AV-E8062; AC-7700; AVE8062), an analogue of combretastatin A4 with improved water solubility, is a novel and potent tubulin inhibitor and vascular-disrupting agent with anticancer activity.
MMAD (also known as Monomethyl auristatin D), an auristatin analog, is a novel and highly potent tubulin inhibitor/antimitotic agent that is often used as a warhead