Venlafaxine (Wy 45030)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$250	Check With Us
500mg	$450	Check With Us
1g	$675	Check With Us

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Cat #: V27970 CAS #: 93413-69-5 Purity ≥ 99%

Description: Venlafaxine free base (Wy-45030; Wy45030; Effexor, Lanvexin, Viepax and Trevilor) is a marketed and arylalkanolamine-based antidepressant acting as an serotonin-norepinephrine reuptake inhibitor (SNRI).

References: Bymaster FP, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	277.40
Molecular Formula	C₁₇H₂₇NO₂
CAS No.	93413-69-5

Protocol	In Vitro	Venlafaxine (Wy 45030) dose-dependently inhibits binding of the serotonin transporter radioligand [3H]-paroxetine to membranes from cells transfected with the human 5-HT transporter with a Ki of 2.48 μM. Venlafaxine inhibits binding of the NE transporter ligand [3H]-nisoxetine to membranes from cells transfected with the human NE transporter with a Ki of 82 nM
	In Vivo	Venlafaxine (Wy 45030; 10-100 mg/kg; IP) dose-dependently blocks the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA
	Animal model	Male Sprague-Dawley rats weighing 180-230 grams
	Dosages	10, 30, 100 mg/kg
	Administration	IP; one hour prior to p-chloramphetamine hydrochloride (p-CA; 10 mg/kg; i.p.)

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.6049 mL	18.0245 mL	36.0490 mL	72.0981 mL
5mM	0.7210 mL	3.6049 mL	7.2098 mL	14.4196 mL
10mM	0.3605 mL	1.8025 mL	3.6049 mL	7.2098 mL
20mM	0.1802 mL	0.9012 mL	1.8025 mL	3.6049 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.