Venlafaxine HCl (Wy 45030 HCl)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$745	Check With Us
10g	$1195	Check With Us
20g	$1790	Check With Us

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Cat #: V1024 CAS #: 99300-78-4 Purity ≥ 98%

Description: Venlafaxine (Wy45030; Wy-45030; Effexor, Effexor XR, Lanvexin, Viepax and Trevilor), an approved and arylalkanolamine-based antidepressant, is an serotonin-norepinephrine reuptake inhibitor (SNRI) used to treat various disorders including major depressive disorder (MDD), panic disorder and social phobia, generalised anxiety disorder (GAD).

References: Bymaster FP, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	313.86
Molecular Formula	C17H27NO2·HCl
CAS No.	99300-78-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 55 mg/mL (176.8 mM)r
	Water: 55 mg/mL (176.8 mM)r
	Ethanol: 55 mg/mL (176.8 mM)
Synonyms	Wy-45030; Trade names: Effexor, Effexor XR, Lanvexin, Viepax and Trevilor. Wy45030; Wy 45030;

Protocol	In Vitro	Venlafaxine hydrochloride (Wy 45030 hydrochloride) dose-dependently inhibits binding of the serotonin transporter radioligand [3H]-paroxetine to membranes from cells transfected with the human 5-HT transporter with a Ki of 2.48 μM. Venlafaxine hydrochloride inhibits binding of the NE transporter ligand [3H]-nisoxetine to membranes from cells transfected with the human NE transporter with a Ki of 82 nM
	In Vivo	Venlafaxine hydrochloride (Wy 45030 hydrochloride; 10-100 mg/kg; IP) dose-dependently blocks the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA
	Animal model	Male Sprague-Dawley rats weighing 180-230 grams
	Dosages	10, 30, 100 mg/kg
	Administration	IP; one hour prior to p-chloramphetamine hydrochloride (p-CA; 10 mg/kg; i.p.)

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.1861 mL	15.9307 mL	31.8613 mL	63.7227 mL
5mM	0.6372 mL	3.1861 mL	6.3723 mL	12.7445 mL
10mM	0.3186 mL	1.5931 mL	3.1861 mL	6.3723 mL
20mM	0.1593 mL	0.7965 mL	1.5931 mL	3.1861 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.