This product is for research use only, not for human use. We do not sell to patients.
| Size | Price | Stock |
|---|---|---|
| 1g | $800 | To Be Confirmed |
| 5g | $2250 | To Be Confirmed |
| 10g | $3375 | To Be Confirmed |
: Cat #: V5179 CAS #: 159857-79-1 Purity ≥ 98%
Description: Val-cit-PAB-OH is a peptide prodrug linker used for the synthesis of ADC durgs such as MC-Val-Cit-PAB (MC-Val-Cit-PAB-OH).MC-Val-Cit-PAB is a novel cathepsin cleavable ADC linker that is utilized for the synthesis of antibody-drug conjugate (ADC) such as some of the FDA approved ADC drugs including brentuximab vedotin. The mechanism is like this: the Val-Cit will specifically be cleaved by catepsin B as this enzyme is only present in the lysosome, the ADC warhead/payload (the drug) will be released in the cell. The Azido group will react with DBCO, BCN or other Alkyne groups through click chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.
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| Molecular Weight (MW) | 379.45 |
|---|---|
| Molecular Formula | C18H29N5O4 |
| CAS No. | 159857-79-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | NC(NCCC[C@H](NC([C@@H](N)C(C)C)=O)C(NC1=CC=C(CO)C=C1)=O)=O |
| Synonyms | Val-cit-PAB-OH |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6354 mL | 13.1770 mL | 26.3539 mL | 52.7079 mL |
| 5mM | 0.5271 mL | 2.6354 mL | 5.2708 mL | 10.5416 mL |
| 10mM | 0.2635 mL | 1.3177 mL | 2.6354 mL | 5.2708 mL |
| 20mM | 0.1318 mL | 0.6588 mL | 1.3177 mL | 2.6354 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.