Boc-Dap-NE is a kind of dipeptide and it is a cleavable ADC linker. Boc-Dap-NE is used in the synthesis of antibody-drug conjugates (ADCs).

DBCO-C6-acid, an analog of DBCO-Acid with an extended 6-carbon atom spacer arm, is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-C6-acid can be used in the synthesis of carmaphycin analogues.

Mc-Val-Ala-PAB is a useful linker to make antibody-drug-conjugate (ADC) for targeting drug delivery.

Fmoc-Phe-Lys(Boc)-PAB is a novel ADC linker used in the synthesis of antibody-drug conjugates (ADC).

Val-cit-PAB-OH is a peptide prodrug linker used for the synthesis of ADC durgs such as MC-Val-Cit-PAB (MC-Val-Cit-PAB-OH).MC-Val-Cit-PAB is a novel cathepsin cleavable ADC linker that is utilized for the synthesis of antibody-drug conjugate (ADC) such as some of the FDA approved ADC drugs including brentuximab vedotin. The mechanism is like this: the Val-Cit will specifically […]

Boc-Val-Cit-PAB-PNP is a novel ADC (Antibody-Drug-Conjugation) used in ADC synthesis.

Boc-NH-PEG4-CH2CH2NH2 is a 5 unit PEG ADC linker that is cleavable and can be used in the synthesis of antibody-drug conjugates (ADCs).

Mc-Val-Cit-PABC-PNP (Mc-Val-Cit-PABC-PNP) is a cathepsin cleavable ADC peptide linker used in the synthesis of antibody-drug conjugates (ADCs). The mechanism is like this: the Val-Cit will specifically be cleaved by catepsin B as this enzyme is only present in the lysosome, the ADC warhead/payload (the drug) will be released in the cell. The Azido group will […]

SPDB is useful heterobifunctional cross-linker, which is widely used to conjugate a small molecule drug to a targeted carrier (such as antibody, enzyme, protein and polymer). SPDB can be used to make ADC (antobody drug conjugate. Conjugated to antibodies utilizing anti-EGFR-SPDB-DM4 has been widely used.

Mc-GGFG-OH is a bifunctional linker used in the synthesis of ADC (antibody drug conjuate). Mc-GGFG-OH contains a carboxy group, which can react with amino group or hydroxy group after activation. Mc-GGFG-OH also contains a maleimido group, which can react with surfuryl group.