UTL-5g
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $2240 | Check With Us |
| 500mg | $3450 | Check With Us |
| 1g | $5175 | Check With Us |
: Cat #: V15441 CAS #: 646530-37-2 Purity ≥ 99%
Description: UTL-5g is a novel and potent chemoprotective agent, TNF-α inhibitor.
References: Stephen Brown, et al. UTL-5g Lowers Levels of TGF-β and TNF-α Elevated by Lung Irradiation
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| Molecular Weight (MW) | 271.10 |
|---|---|
| Molecular Formula | C11H8Cl2N2O2 |
| CAS No. | 646530-37-2 |
| SMILES Code | O=C(C1=NOC(C)=C1)NC2=CC=C(Cl)C=C2Cl |
| Synonyms | UTL-5g; UTL 5g; UTL5g; |
| Protocol | In Vitro | RAW 264.7 macrophages are transfected with the respective reporter assay plasmids, pretreated with UTL-5g at 1, 10 or 50 µM for 60 min and then challenged with 100 ng/ml LPS. After a 16 h incubation, transcription factor activity is measured. Transcription factors that shows a UTL-5g dose-dependent decrease in activity in two experiments are categorized as being disrupted by UTL-5g. |
|---|---|---|
| In Vivo | UTL-5g (GBL-5g) lowers levels of TGF-β and TNF-α elevated by lung irradiation. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6887 mL | 18.4434 mL | 36.8868 mL | 73.7735 mL |
| 5mM | 0.7377 mL | 3.6887 mL | 7.3774 mL | 14.7547 mL |
| 10mM | 0.3689 mL | 1.8443 mL | 3.6887 mL | 7.3774 mL |
| 20mM | 0.1844 mL | 0.9222 mL | 1.8443 mL | 3.6887 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.