Ulodesine (BCX4208)

This product is for research use only, not for human use. We do not sell to patients.

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Cat #: V3307 CAS #: 548486-59-5 Purity ≥ 98%

Description: Ulodesine (formerly also known as BCX4208) is a novel and potent inhibitor of purine nucleoside phosphorylase (PNP) with the potential to be used for the treatment of psoriasis and gout. It inhibits PNP with an IC50 of 0.5 nM. It is currently being developed by Biocryst as a once-daily oral, chronic treatment for gout. Ulodesine acts at the upstream of xanthine oxidase in the purine metabolism pathway to reduce the production of serum uric acid (sUA) by inhibiting PNP. BCX-4208 is currently in early clinical investigation in psoriasis and gout.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	264.28
Molecular Formula	C12H16N4O3
CAS No.	548486-59-5
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ≥ 10mg/mL
	Water: N/A
	Ethanol: N/A
SMILES Code	O=C1C(NC=C2CN3C[C@H](O)[C@@H](CO)C3)=C2N=CN1
Synonyms	BCX4208; BCX-4208; BCX 4208; DADMe-immucillin H

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.7839 mL	18.9193 mL	37.8387 mL	75.6773 mL
5mM	0.7568 mL	3.7839 mL	7.5677 mL	15.1355 mL
10mM	0.3784 mL	1.8919 mL	3.7839 mL	7.5677 mL
20mM	0.1892 mL	0.9460 mL	1.8919 mL	3.7839 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.