TRX-0237 mesylate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$900	Check With Us
1g	$1350	Check With Us
5g	$4050	Check With Us

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Cat #: V16894 CAS #: 1236208-20-0 Purity ≥ 98%

Description: TRX-0237 mesylate (LMT-X; TRX0237; Leuco-MTx; LMTX; Hydromethylthionine mesylate), the mesylate salt of TRX 0237 which is currently in phase III clinical trials by TauRx, is a 2nd-generation tau protein aggregation and TDP-43 aggregation inhibitor with the potential for the treatment of Alzheimer's disease (AD) and frontotemporal dementia.

References: Gaudette NF, et al. Determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine andB6C3F1 mouse urine. J Anal Toxicol. 2005 Jan-Feb;29(1):28-33.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	477.62
Molecular Formula	C18H27N3O6S3
CAS No.	1236208-20-0

Protocol	In Vitro	Leucomethylene blue (100 nM, 48 h) mesylate not only decreases the tau and p-tau expression levels, but also reversed the promoting effects of Aβ25-35 on orexin A and adenosine A1R expression levels

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0937 mL	10.4686 mL	20.9371 mL	41.8743 mL
5mM	0.4187 mL	2.0937 mL	4.1874 mL	8.3749 mL
10mM	0.2094 mL	1.0469 mL	2.0937 mL	4.1874 mL
20mM	0.1047 mL	0.5234 mL	1.0469 mL	2.0937 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.