Trovafloxacin mesylate

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
50mg	$1100	Check With Us
100mg	$1650	Check With Us
200mg	$2475	Check With Us

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Cat #: V16878 CAS #: 147059-75-4 Purity ≥ 98%

Description: Trovafloxacin mesylate (CP-99219) is a broad-spectrum quinolone antibiotic that inhibits DNA supercoiling in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV.

References: Giustarini G, et al. The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	512.46
Molecular Formula	C21H19F3N4O6S
CAS No.	147059-75-4
SMILES Code	O=C(C1=CN(C2=CC=C(F)C=C2F)C3=NC(N4C[C@@]5([H])C(N)[C@@]5([H])C4)=C(F)C=C3C1=O)O.CS(=O)(O)=O
Synonyms	CP-99219; CP 99219; CP99219; CP 99,219; CP 99219; CP-99,219; Trovafloxacin mesylate; Trovan

Protocol	In Vitro	Trovafloxacin (20 µM; 24 hours; HepG2 cells) and tumor necrosis factor (TNF; 4 ng/mL) incubation induces apoptosis and increases leakage of lactate dehydrogenase (LDH) in HepG2 cells
	In Vivo	Trovafloxacin (150 mg/kg; oral administration; male C57BL/6 J mice) treatment disrupts TNF-induced p65 nuclear translocation. Trovafloxacin treatment increases expression of early NF-κB-related factors A20 and IκBα
	Animal model	Male C57BL/6 J mice (9-11-week-old) injected with recombinant murine TNF ion
	Dosages	150 mg/kg
	Administration	Oral administration; once

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.9514 mL	9.7569 mL	19.5137 mL	39.0274 mL
5mM	0.3903 mL	1.9514 mL	3.9027 mL	7.8055 mL
10mM	0.1951 mL	0.9757 mL	1.9514 mL	3.9027 mL
20mM	0.0976 mL	0.4878 mL	0.9757 mL	1.9514 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.