Tropisetron HCl (SDZ-ICS-930 HCl)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
10g	$650	Check With Us
25g	$1150	Check With Us
50g	$1725	Check With Us

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Cat #: V1035 CAS #: 105826-92-4 Purity ≥ 98%

Description: Tropisetron HCl (Navoban; ICS-205930; ICS 205-930), the hydrochloride salt of Tropisetron which is an anti-emetic drug, is a novel, potent and selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist that has been approved for the treatment of chemotherapy-induced nausea and vomiting.

References: Rahimian R, et al. Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats. Eur J Clin Invest. 2013 Oct;43(10):1039-51.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	320.81
Molecular Formula	C17H20N2O2.HCl
CAS No.	105826-92-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 35 mg/mL (109.1 mM)r
	Water: 46 mg/mL (143.4 mM)r
	Ethanol: <1 mg/mL
Synonyms	Trade name Navoban; ICS-205930; ICS 205-930; Tropisetron; ICS 205930; ICS205930; ICS 205-930; ICS-205-930; Tropisetron HCl;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.1171 mL	15.5855 mL	31.1711 mL	62.3422 mL
5mM	0.6234 mL	3.1171 mL	6.2342 mL	12.4684 mL
10mM	0.3117 mL	1.5586 mL	3.1171 mL	6.2342 mL
20mM	0.1559 mL	0.7793 mL	1.5586 mL	3.1171 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.