Troglitazone

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$900	Check With Us
500mg	$1450	Check With Us
1g	$2175	Check With Us

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Cat #: V2726 CAS #: 97322-87-7 Purity ≥ 98%

Description: Troglitazone (formerly known as CI991) is a novel potent PPARγ agonist with anti-inflammatory and anti-tumor activity.

References: Willson TM, et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	441.54
Molecular Formula	C24H27NO5S
CAS No.	97322-87-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 88 mg/mL (199.3 mM)r
	Water: <1 mg/mLr
	Ethanol: 15 mg/mL (34 mM)
SMILES Code	O=C(N1)SC(CC2=CC=C(OCC3(C)CCC4=C(C)C(O)=C(C)C(C)=C4O3)C=C2)C1=O
Synonyms	Rezulin, Romglizone, Romozin, Prelay, CS-045, CS045; CI-991; CI991; CI 991; CS-045; GR 92132X; GR92132X; Prelay; Troglitazone; Rezulin, Resulin, Romozin, Noscal.

Protocol	In Vitro	Troglitazone is a PPARγ agonist, with EC50s of 550 nM and 780 nM for human and murine PPARγ receptor, respectively.
Protocol	In Vivo	Troglitazone (200 mg/kg, p.o.) shows inhibitory effects on the growth of tumor in the MIA Paca2 xenograft model.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2648 mL	11.3240 mL	22.6480 mL	45.2960 mL
5mM	0.4530 mL	2.2648 mL	4.5296 mL	9.0592 mL
10mM	0.2265 mL	1.1324 mL	2.2648 mL	4.5296 mL
20mM	0.1132 mL	0.5662 mL	1.1324 mL	2.2648 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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