Troglitazone (formerly known as CI991) is a novel potent PPARγ agonist with anti-inflammatory and anti-tumor activity.

Alpinetin is a natural flavonoid isolated from Alpinia katsumadai Hayata with potent anti-inflammatory activity.

GW0742 (GW-0742; GW 0742; GW-0742X; GW0742X; GW610742; GW-610742) is a potent and highly selective PPARβ/δ agonist with potential anti-inflammatory activity.

Clofibric acid (BRN-1874067; CCRIS 9254; BRN1874067; NSC 1149; NSC1149; Chlorofibrinic acid), the active metabolite of clofibrate, etofibrate and theofibrate (the lipid-lowering drugs), is a potent PPARα agonist and anti-hyperlipidemic agent.

BMS-687453 is a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with an EC50 and IC50 of 10 nM and 260 nM for human PPARα and 4100 nM and >15000 nM for PPARγ in PPAR-GAL4 transactivation assays.

Fenofibrate (Tricor, Procetofen, LF-178, Lipanthyl, NSC-281319; Controlip, Normalip, Secalip, durafenat, Trilipix) is a fibric acid based anti-hyperlipidemic drug of the fibrate class approved for clinical uses as a lipid-lowering agent.

Ciprofibrate (BRN-1984981; CCRIS 173; CCRIS173; Win-35833; BRN 1984981; BRN1984981;CCRIS-173) is a potent and selective agonist of PPAR/peroxisome proliferator-activated receptor agonist with antilipidemic activity.

Bezafibrate (BM 15075; BM-15075; Benzofibrate; BM15075; Bezalip; Bezatrol; Difaterol; Cedur; Bezafibratum) is an anti-hypertriglyceridemic/lipid-lowering drug acting.

Pemafibrate [(R)-K 13675; K877; Parmodia], a drug used for the reduction of triglycerides, is a potent agonist of peroxisome proliferator-activated receptor alpha (PPAR alpha/PPARα) with EC50 of 1 nM.

Gemfibrozil (Pilder; CI-719; CI719; CI 719; Lopid; Jezil; Lipur; Trialmin) is a potent anti-hypertriglyceridemic/lipid lowering drug acting as an activator/agonist of peroxisome proliferator-activated receptor-alpha (PPARα).