Toremifene
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $380 | Check With Us |
| 10g | $620 | Check With Us |
| 20g | $930 | Check With Us |
: Cat #: V16600 CAS #: 89778-26-7 Purity ≥ 98%
Description: Toremifene (NSC 613680; NK 622; FC 1157a) is an orally bioavailable and second-generation SERM (selective estrogen receptor modulator) used in the treatment of advanced breast cancer.
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| Molecular Weight (MW) | 405.97 |
|---|---|
| Molecular Formula | C26H28ClNO |
| CAS No. | 89778-26-7 |
| SMILES Code | ClCC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)C3=CC=CC=C3 |
| Synonyms | GTx 006; Z-Toremifene; Acapodene |
| Protocol | In Vitro | The growth of Ac-1 cells was inhibited by tamoxifen, toremifene and atamestane in vitro with IC50values of 1.8±1.3μM, 1±0.3μM and 60.4±17.2μM, respectively. The combination of toremifene plusatamestane was found to be better than toremifene or atamestane alone in vitro |
|---|---|---|
| In Vivo | The effect of this combination was then studied in vivo using Ac-1 xenografts grown in ovariectomized female SCID mice. The mice were injected with toremifene (1000μg/day), atamestane (1000μg/day), tamoxifen (100μg/day), or the combination of toremifene plus atamestane. In this study, our results indicate that the combination of toremifene plus atamestane was as effective as toremifene or tamoxifen alone but may not provide any additional benefit over toremifene alone or tamoxifen alone |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4632 mL | 12.3162 mL | 24.6324 mL | 49.2647 mL |
| 5mM | 0.4926 mL | 2.4632 mL | 4.9265 mL | 9.8529 mL |
| 10mM | 0.2463 mL | 1.2316 mL | 2.4632 mL | 4.9265 mL |
| 20mM | 0.1232 mL | 0.6158 mL | 1.2316 mL | 2.4632 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.