TNO155 | CAS 1801765-04-7

TNO155

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Size	Price	Stock
100mg	$1150	Check With Us
200mg	$1725	Check With Us
500mg	$2910	Check With Us

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Cat #: V2183 CAS #: 1801765-04-7 Purity ≥ 98%

Description: TNO155 (TNO-155) is an inhibitor of protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11; IC50=11 nM) with potential anticancer activity.

References: TNO155: SHP2 inhibitor

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Molecular Weight (MW)	421.95
Molecular Formula	C18H24ClN7OS
CAS No.	1801765-04-7
SMILES Code	N[C@@H]1[C@@H](OCC12CCN(CC2)C3=NC(N)=C(SC4=C(Cl)C(N)=NC=C4)N=C3)C
Synonyms	TNO155; TNO-155; TNO 155; batoprotafib

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3699 mL	11.8497 mL	23.6995 mL	47.3990 mL
5mM	0.4740 mL	2.3699 mL	4.7399 mL	9.4798 mL
10mM	0.2370 mL	1.1850 mL	2.3699 mL	4.7399 mL
20mM	0.1185 mL	0.5925 mL	1.1850 mL	2.3699 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.