TLR7/8 agonist 1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1950 | Check With Us |
| 500mg | $3250 | Check With Us |
| 1g | $4875 | Check With Us |
: Cat #: V40861 CAS #: 1258457-59-8 Purity ≥ 99%
Description: TLR7/8 agonist 1 is an agonist of TLR7/8 that can be used as an adjuvant for skin treatment of virus-associated warts and basal cell carcinoma.
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| Molecular Weight (MW) | 359.47 |
|---|---|
| Molecular Formula | C22H25N5 |
| CAS No. | 1258457-59-8 |
| SMILES Code | OC(C(F)(F)F)=O.NCC1=CC=C(CN2C(C3=CC=CC=C3N=C4N)=C4N=C2CCCC)C=C1 |
| Synonyms | TLR7/8 agonist-7d, TLR7/8 agonist -7d, TLR7/8-agonist 7d |
| Protocol | In Vitro | TLR7/8 agonist 1 (Compound 5d) shows prominent immunostimulatory activities. TLR7/8 agonist 1 serves as a convenient precursor for the covalent attachment of fluorophores without significant loss of activity.TLR7/8 agonist 1 retains TLR7-agonistic activity with an EC50 of 20 nM. TLR7/8 agonist 1 is covalently coupled directly to commercially-available fluorescein isothiocyanate and rhodamine B isothiocyanate. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7819 mL | 13.9094 mL | 27.8187 mL | 55.6375 mL |
| 5mM | 0.5564 mL | 2.7819 mL | 5.5637 mL | 11.1275 mL |
| 10mM | 0.2782 mL | 1.3909 mL | 2.7819 mL | 5.5637 mL |
| 20mM | 0.1391 mL | 0.6955 mL | 1.3909 mL | 2.7819 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.