CU-CPT-8m is a novel, potent and specific antagonist of Toll-like receptor 8 (TLR8) with immunomodulatory effects.

DSR-6434 (DSR6434) is a novel and selective Toll-like receptor 7 (TLR7) agonist with antitumor effects.

Enpatoran (M-5049) is a novel and selective inhibitor of Toll-Like Receptor 7/8 with IC50 of 11.1 and 24 nM, respectively.

SM-324405 (SM324405; SM 324405) is a novel and potent TLR7 (toll-like receptor 7) agonist designed by introducing the antedrug concept with reduced systemic activity.

Okanin is a novel and potent bioactive compound.

Resiquimod (formerly known as R-848; S-28463; VML-600; R848, S27609) is a potent imidazoquinolinamine-based immune response modifier that acts as an agonist of the TLR 7/8 receptors (Toll-like receptor 7/8) with antiviral and antitumour activity.

Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is an analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors with the potential to be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment.

CU-T12-9 (CU T12-9; CU-T129) is a novel and potent TLR1/2 (Toll-like receptor) agonist with potential immunemodulatory and antitumor effects.

TLR4-IN-C34 is a novel and orally bioactive TLR4 inhibitor that reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.

Motolimod (also known as VTX-2337; VTX 378; VTX2337) is a novel, selective and potent small molecule agonist of the Toll-like receptor (TLR) 8 with immunostimulating/modulatory and anticancer effects.