Tizanidine HCl (BRN 0618691; AB 021)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$750	Check With Us
10g	$1050	Check With Us
20g	$1575	Check With Us

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Cat #: V1110 CAS #: 64461-82-1 Purity ≥ 98%

Description: Tizanidine HCl (AB 021 ; AN 021; DS 103-282; BRN-0618691; Sirdalud; Ternelin), the hydrochloride salt of tizanidine, is an alpha2/α2-adrenergic receptor agonist that has been approved for use mainly as a muscle relaxant to treat spasms, cramping, and tightness of muscles.

References: Kamen L, et al. A practical overview of tizanidine use for spasticity secondary to multiple sclerosis, stroke, and spinal cord injury. Curr Med Res Opin. 2008 Feb;24(2):425-39.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	290.17
Molecular Formula	C9H8ClN5S.HCl
CAS No.	64461-82-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 10 mg/mL (34.5 mM)r
	Water: 15 mg/mL (51.69 mM)r
	Ethanol: <1 mg/mL
Synonyms	BRN0618691; AB 021 ; AN 021; DS 103-282; BRN-0618691; BRN 0618691; Tizanidine; Tizanidine hydrochloride; Sirdalud; Ternelin.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.4463 mL	17.2313 mL	34.4626 mL	68.9251 mL
5mM	0.6893 mL	3.4463 mL	6.8925 mL	13.7850 mL
10mM	0.3446 mL	1.7231 mL	3.4463 mL	6.8925 mL
20mM	0.1723 mL	0.8616 mL	1.7231 mL	3.4463 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.