Tirapazamine
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $250 | In Stock |
| 1g | $450 | In Stock |
| 5g | $1210 | In Stock |
: Cat #: V2905 CAS #: 27314-97-2 Purity ≥ 98%
Description: Trapazamine (also known as TP, SR-4233; SR259075; Win59075; SR4233) is an experimental adjuvant drug and a DNA-damaging agent that has the potential for the treatment of cervical carcinoma, head and neck cancer.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 178.05 |
|---|---|
| Molecular Formula | C7H6N4O2 |
| CAS No. | 27314-97-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 40 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: | |
| SMILES Code | NC1=[N+]([O-])C2=CC=CC=C2[N+]([O-])=N1 |
| Synonyms | SR 4233; SR-4233; SR4233; SR259075; SR-259075; SR 259075; WIN 59075; WIN-59075; WIN59075; NSC130181; NSC-130181; NSC 130181;Tirazone; TP; Tirapazamine; Chemical Name: 3-aminobenzo[e][1,2,4]triazine 1,4-dioxide Exact Mass: 178.04908 |
| Protocol | In Vitro | Tirapazamine (SR259075) is the optimal drug for combination therapy using Pba |
|---|---|---|
| In Vivo | Tirapazamine (SR259075) (1mg; intravenously injected; twice at a 24-h interval) shows a synergetic effect to kill tumor cells because TPZ was activated under the hypoxic conditions that originated from the PDT with Pba and laser irradiation | |
| Animal model | C3H/HeN mice | |
| Dosages | 1mg | |
| Administration | Tirapazamine (1mg; intravenously injected; twice at a 24-h interval) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 5.6164 mL | 28.0820 mL | 56.1640 mL | 112.3280 mL |
| 5mM | 1.1233 mL | 5.6164 mL | 11.2328 mL | 22.4656 mL |
| 10mM | 0.5616 mL | 2.8082 mL | 5.6164 mL | 11.2328 mL |
| 20mM | 0.2808 mL | 1.4041 mL | 2.8082 mL | 5.6164 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.