Tiagabine hydrochloride

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$350	145821-59-6
500mg	$525	145821-59-6
1g	$790	145821-59-6

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Cat #: V14286 CAS #: 145821-59-6 Purity ≥ 99%

Description: Tiagabine HCl (NNC-05-0328; NO-05-0328; NO329; NNC-050328; NO 329; trade name Gabitril), the hydrochloride salt of tiagabine, is an marketed anticonvulsant acting as a selective GABA (gamma-aminobutyric acid) reuptake inhibitor, may also be used for the treatment of panic disorders.

References: Braestrup C, et al. (R)-N-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]nipecotic acid binds with high affinity to the brain gamma-aminobutyric acid uptake carrier. J Neurochem. 1990 Feb;54(2):639-47.

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Molecular Weight (MW)	412.01
Molecular Formula	C20H26ClNO2S2
CAS No.	145821-59-6

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4271 mL	12.1356 mL	24.2713 mL	48.5425 mL
5mM	0.4854 mL	2.4271 mL	4.8543 mL	9.7085 mL
10mM	0.2427 mL	1.2136 mL	2.4271 mL	4.8543 mL
20mM	0.1214 mL	0.6068 mL	1.2136 mL	2.4271 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.