Tenofovir disoproxil (GS 4331)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $445 | Check With Us |
| 10g | $645 | Check With Us |
| 20g | $965 | Check With Us |
: Cat #: V12260 CAS #: 201341-05-1 Purity ≥ 98%
Description: Tenofovir disoproxil [Bis(POC)-PMPA; GS 4331)] is an antiretroviral drug and prodrug of Tenofovir, acting as a nucleotide reverse transcriptase inhibitor to prevent and treat HIV/AIDS and to treat chronic hepatitis B.
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| Molecular Weight (MW) | 519.4478 |
|---|---|
| Molecular Formula | C19H30N5O10P |
| CAS No. | 201341-05-1 |
| SMILES Code | NC1=C2C(N(C[C@H](OCP(OCOC(OC(C)C)=O)(OCOC(OC(C)C)=O)=O)C)C=N2)=NC=N1 |
| Synonyms | GS 4331; GS-4331; GS4331; Bis(POC)PMPA; PMPA prodrug |
| Protocol | In Vitro | Tenofovir shows cytotoxic effects on cell viability in HK-2 cells, with IC50 values of 9.21 and 2.77 μM at 48 and 72 h in MTT assay, respectively. Tenofovir diminishes ATP levels in HK-2 cells. Tenofovir (3.0 to 28.8 μM) increases oxidative stress and protein carbonylation in HK-2 cells. Furthermore, Tenofovir induces apoptosis in HK-2 cells, and that apoptosis is induced via mitochondrial damage |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9251 mL | 9.6256 mL | 19.2512 mL | 38.5024 mL |
| 5mM | 0.3850 mL | 1.9251 mL | 3.8502 mL | 7.7005 mL |
| 10mM | 0.1925 mL | 0.9626 mL | 1.9251 mL | 3.8502 mL |
| 20mM | 0.0963 mL | 0.4813 mL | 0.9626 mL | 1.9251 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.