Tegafur (FT-207; NSC 148958)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$245	Check With Us
10g	$445	Check With Us
20g	$668	Check With Us

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Cat #: V1479 CAS #: 17902-23-7 Purity ≥ 98%

Description: Tegafur (formerly known as Fluorafur, FT-207, NSC-148958; Uftoral; UFT), a component of tegafur-uracil, is a chemotherapeutic anticancer prodrug of 5-FU (5-Fluorouracil, an anticancer drug) that is commonly used in the treatment of various cancers.

References: José L. Ariasa, et al. Engineering of an antitumor (core/shell) magnetic nanoformulation based on the chemotherapy agent ftorafur. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2011,384(1-3): 157-163.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	200.17
Molecular Formula	C8H9FN2O3
CAS No.	17902-23-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 40 mg/mL (199.8 mM)r
	Water: 8 mg/mL (40 mM)r
	Ethanol: 7 mg/mL (35 mM)
Solubility In Vivo	Chemical Name: 5-fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione InChi Key: WFWLQNSHRPWKFK-UHFFFAOYSA-N InChi Code: InChI=1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13) SMILES Code: O=C1NC(C(F)=CN1C2OCCC2)=O
Synonyms	Fluorafur, FT-207, NSC-148958; FT207, NSC148958; FT 207, NSC 148958; Uracil and Ftorafur; Uracil and Tegafur; Trade name: Uftoral; UFT.

Protocol	In Vitro	Tegafur is bioactivated to 5-FU by liver microsomal cytochrome P450 enzymes. 5-FU is subsequently converted into its active metabolites 5-fluoro-deoxyuridine-monophosphate (FdUMP) and 5-fluorouridine-triphosphate (FUTP) intracellularly; these metabolites inhibit the enzyme thymidylate synthase and intercalate into RNA, resulting in decreased thymidine synthesis, reduced DNA synthesis, disrupted RNA function, and tumor cell cytotoxicity

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.9958 mL	24.9788 mL	49.9575 mL	99.9151 mL
5mM	0.9992 mL	4.9958 mL	9.9915 mL	19.9830 mL
10mM	0.4996 mL	2.4979 mL	4.9958 mL	9.9915 mL
20mM	0.2498 mL	1.2489 mL	2.4979 mL	4.9958 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.