TCS-PIM-1-4a (SMI-4a)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $470 | Check With Us |
| 1g | $700 | Check With Us |
| 5g | $1770 | Check With Us |
: Cat #: V3233 CAS #: 327033-36-3; (Z)-SMI-4a Purity ≥ 98%
Description: TCS-PIM-1-4a ( (the mixture of E- and Z-enantiomers of SMI-4a) is a novel Pim inhibitor with IC50 of 13 nM for Pim-1 and 2.3 μM for Pim-2.
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| Molecular Weight (MW) | 273.23 |
|---|---|
| Molecular Formula | C11H6F3NO2S |
| CAS No. | 327033-36-3; (Z)-SMI-4a |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mM in DMSOr |
| Water: <1 mg/mLr | |
| Ethanol: | |
| SMILES Code | O=C(NC/1=O)SC1=CC2=CC=CC(C(F)(F)F)=C2 |
| Synonyms | TCS PIM-1 4a; SMI-4a; SMI4a; SMI 4a |
| Protocol | In Vivo | SMI-4a (SMI-4a; 60 mg/kg; oral gavage; twice daily; for 21 days; nu/nu nude mice) treatment causes a significant delay in the tumor growth without any change in the weight, blood counts, or chemistries. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6599 mL | 18.2996 mL | 36.5992 mL | 73.1984 mL |
| 5mM | 0.7320 mL | 3.6599 mL | 7.3198 mL | 14.6397 mL |
| 10mM | 0.3660 mL | 1.8300 mL | 3.6599 mL | 7.3198 mL |
| 20mM | 0.1830 mL | 0.9150 mL | 1.8300 mL | 3.6599 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.