TAS-102 (Trifluridine/Tipiracil HCl)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $645 | Check With Us |
| 500mg | $845 | Check With Us |
| 1g | $1265 | Check With Us |
: Cat #: V13524 CAS #: 733030-01-8 Purity ≥ 98%
Description: TAS-102 (a mixture of Trifluridine and tipiracil hydrochloride in a 1:0.5 molar ratio) is a combination drug under investigation for treating metastatic colorectal cancer.
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| Molecular Weight (MW) | 435.76 |
|---|---|
| CAS No. | 733030-01-8 |
| Synonyms | TAS102, TAS-102, TAS 102, Trifluridine/tipiracil hydrochloride |
| Protocol | In Vivo | Trifluridine/tipiracil hydrochloride mixture (150 mg/kg/day; p.o.; twice a day for 14 days) prevents body weight loss and reduces the relative tumor volume in colorectal cancer and gastric cancer mice models |
|---|---|---|
| Animal model | Male nude mice bearing KM12C, KM12C/5-FU, DLD-1, DLD-1/5-FU, and SC-2 cells | |
| Dosages | 150 mg/kg/day | |
| Administration | p.o.; twice a day for 14 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2948 mL | 11.4742 mL | 22.9484 mL | 45.8968 mL |
| 5mM | 0.4590 mL | 2.2948 mL | 4.5897 mL | 9.1794 mL |
| 10mM | 0.2295 mL | 1.1474 mL | 2.2948 mL | 4.5897 mL |
| 20mM | 0.1147 mL | 0.5737 mL | 1.1474 mL | 2.2948 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.