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Tamoxifen

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Tamoxifen
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Cat #: V1742 CAS #: 10540-29-1 Purity ≥ 98%

Description: Tamoxifen (ICI-46474; NSC-180973; Nolvadex; Novaldex) is a potent and selective estrogen receptor modulator (SERM) with potential antitumor activity.

References: Osborne CK. Tamoxifen in the treatment of breast cancer. N Engl J Med. 1998 Nov 26;339(22):1609-18.

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Molecular Weight (MW)371.51
Molecular FormulaC26H29NO
CAS No.10540-29-1
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 74 mg/mL (199.2 mM)r
Water: <1 mg/mLr
Ethanol: 74 mg/mL (199.2 mM)
Solubility In VivoCorn oil: 40 mg/mL or 107.67 mM
SMILES CodeCC/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)/C3=CC=C(OCCN(C)C)C=C3v
Synonymstamoxifeni citras, Nolvadex, Novalde, Tamoxifen;ICI 46474, ICI-46474, ICI46474, NSC 180973, tamoxifen,
ProtocolIn VitroTamoxifen (ICI 47699) shows strong inhibition of MCF-7 cells (EC50=1.41 μM) and to a lesser extent the T47D cells (EC50=2.5 μM) but does not affect the MDA-MB-231 cells.
In VivoInjection of pre-mutant mice with Tamoxifen (75 mg/kg; injected for 5 days at 6 weeks of age) results in the excision of the floxed exon and, thus, in a gene knockout.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6917 mL13.4586 mL26.9172 mL53.8344 mL
5mM0.5383 mL2.6917 mL5.3834 mL10.7669 mL
10mM0.2692 mL1.3459 mL2.6917 mL5.3834 mL
20mM0.1346 mL0.6729 mL1.3459 mL2.6917 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.