Taltobulin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50mg | $950 | To Be Confirmed |
| 100mg | $1425 | To Be Confirmed |
| 200mg | $2137 | To Be Confirmed |
: Cat #: V7586 CAS #: 228266-40-8 Purity ≥ 99%
Description: Taltobulin (HTI-286; SPA-110), an analog of the natural tripeptide hemiasterlin, is a tubulin inhibitor with anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 473.65 |
|---|---|
| Molecular Formula | C27H43N3O4 |
| CAS No. | 228266-40-8 |
| Protocol | In Vitro | TaltobuLin (HTI-286； 0.2-7.3 nM； 3 days) Inhibition of growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines), mean IC50 is 2.5±2.1 nM, with a median of 1.7 nM |
|---|---|---|
| In Vivo | TaltobuLin (HTI-286; 1.6 mg/kg; iv) Inhibit tumor growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) in athymic nu/nu female mice |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1113 mL | 10.5563 mL | 21.1126 mL | 42.2253 mL |
| 5mM | 0.4223 mL | 2.1113 mL | 4.2225 mL | 8.4451 mL |
| 10mM | 0.2111 mL | 1.0556 mL | 2.1113 mL | 4.2225 mL |
| 20mM | 0.1056 mL | 0.5278 mL | 1.0556 mL | 2.1113 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.