Talmapimod (SCIO 469)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1150 | Check With Us |
| 250mg | $2050 | Check With Us |
| 500mg | $3075 | Check With Us |
: Cat #: V30970 CAS #: 309913-83-5 Purity ≥ 99%
Description: Talmapimod, formerly known as SCIO-469, is a novel, orally bioavailable, and selective p38 mitogen-activated protein kinase (MAPK) inhibitor (IC50 = 9 nM) with potential immunomodulating, anti-inflammatory, and antineoplastic activities.
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| Molecular Weight (MW) | 513.00 |
|---|---|
| Molecular Formula | C27H30ClFN4O3 |
| CAS No. | 309913-83-5 |
| SMILES Code | O=C(N(C)C)C(C1=CN(C)C2=C1C=C(C(N3[C@H](C)CN(CC4=CC=C(F)C=C4)[C@@H](C)C3)=O)C(Cl)=C2)=O |
| Synonyms | SD282, SD-282, SD 282, SCIO282, SCI O282, SCI-O282, Talmapimod |
| Protocol | In Vitro | Talmapimod (SCIO-469) (100-200 nM; 1 hour) inhibits phosphorylation of p38 MAPK in MM cells. |
|---|---|---|
| In Vivo | Targeting p38α MAPK with Talmapimod (SCIO-469) decreases myeloma burden in addition to preventing the development of myeloma bone disease. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9493 mL | 9.7466 mL | 19.4932 mL | 38.9864 mL |
| 5mM | 0.3899 mL | 1.9493 mL | 3.8986 mL | 7.7973 mL |
| 10mM | 0.1949 mL | 0.9747 mL | 1.9493 mL | 3.8986 mL |
| 20mM | 0.0975 mL | 0.4873 mL | 0.9747 mL | 1.9493 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.