Suprofen (TN-762)

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$739	Check With Us
1g	$1150	Check With Us
5g	$2700	Check With Us

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Cat #: V1077 CAS #: 40828-46-4 Purity ≥ 98%

Description: Suprofen (R25061; TN762; R-25061; TN-762; Suprofen; Suprofenum; Profenal), a nonsteroid anti-inflammatory drug (NSAID), is a potent and nonselective dual inhibitor of COX-1/COX-2 enzymes with potential anti-inflammatory and antipyretic activity.

References: Yeadon, A., et al., Suprofen. An overview of long-term safety. Pharmacology, 1983. 27 Suppl 1: p. 87-94.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	260.31
Molecular Formula	C14H12O3S
CAS No.	40828-46-4
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 52 mg/mL (199.8 mM)rr
	Water: <1 mg/mLrr
	Ethanol: 52 mg/mL (199.8 mM)
Solubility In Vivo	Chemical Name: 2-(4-(thiophene-2-carbonyl)phenyl)propanoic acid InChi Key: MDKGKXOCJGEUJW-UHFFFAOYSA-N InChi Code: InChI=1S/C14H12O3S/c1-9(14(16)17)10-4-6-11(7-5-10)13(15)12-3-2-8-18-12/h2-9H,1H3,(H,16,17) SMILES Code: CC(C1=CC=C(C(C2=CC=CS2)=O)C=C1)C(O)=O
SMILES Code	CC(C1=CC=C(C(C2=CC=CS2)=O)C=C1)C(O)=O
Synonyms	R-25061;TN-762; R25061; TN 762; R 25061; TN762; Suprofen; Suprofenum; Profenal

Protocol	In Vitro	Suprofen (TN-762) is an NSAID. Suprofen (TN-762) is an ibuprofen-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic. suprofen was clinically effective but the differential suppression of prostanoids favors 200mg which spares 6-keto PGF1a

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.8416 mL	19.2079 mL	38.4157 mL	76.8315 mL
5mM	0.7683 mL	3.8416 mL	7.6831 mL	15.3663 mL
10mM	0.3842 mL	1.9208 mL	3.8416 mL	7.6831 mL
20mM	0.1921 mL	0.9604 mL	1.9208 mL	3.8416 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.