Suplatast Tosylate (IPD 1151T)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $200 | Check With Us |
| 1g | $360 | Check With Us |
| 5g | $910 | Check With Us |
: Cat #: V2089 CAS #: 94055-76-2 Purity ≥ 98%
Description: Suplatast Tosilate (also known as IPD-1151T) is a novel capsular anti-asthmatic and anti-allergic agent that suppresses both IgE production, IL-4 and IL-5 synthesis with IC50 above 100 μM.
Top Publications Citing Invivochem Products
Publications Citing InvivoChem Products
Product Promise
- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 499.64 |
|---|---|
| Molecular Formula | C23H33NO7S2 |
| CAS No. | 94055-76-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (200.1 mM)r |
| Water: 100 mg/mL (200.1 mM)r | |
| Ethanol: N/A | |
| Solubility In Vivo | Saline: 30 mg/mL |
| SMILES Code | C[S+](CCC(NC1=CC=C(OCC(O)COCC)C=C1)=O)C.CC2=CC=C(S(=O)([O-])=O)C=C2 |
| Synonyms | IPD-1151T; IPD 1151T; IPD1151T |
| Protocol | In Vitro | IPD-1151T (1-10 μM; 24 h) clearly depresses phytohemagglutinin (PHA)-induced expression of IL-4 mRNA in normal peripheral blood mononuclear cells (PBMC). IPD-1151T (1-10 μM; 10 d) induces a concentration-dependent suppression of purified allergen (Cry j 1)-dependent IgE synthesis in autologous B cell cultures mediated by SN-4, without significantly affecting the IgG synthesis. |
|---|---|---|
| In Vivo | Suplatast Tosilate (100 mg/kg; once daily for 21 d) inhibits the production of Th2 cytokines, which inhibits eosinophil infiltration into the murine airway, IgE synthesis, and development of BHR, in a murine model of asthma. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0014 mL | 10.0072 mL | 20.0144 mL | 40.0288 mL |
| 5mM | 0.4003 mL | 2.0014 mL | 4.0029 mL | 8.0058 mL |
| 10mM | 0.2001 mL | 1.0007 mL | 2.0014 mL | 4.0029 mL |
| 20mM | 0.1001 mL | 0.5004 mL | 1.0007 mL | 2.0014 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.