Sulindac Sulfide
This product is for research use only, not for human use. We do not sell to patients.
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Cat #: V8418 CAS #: 49627-27-2 Purity ≥ 99%
Description: Sulindac Sulfide (cis-Sulindac sulfide), a major metabolite of sulindac which is is a nonsteroidal anti-inflammatory drug (NSAID), is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.
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Molecular Weight (MW) | 340.41 |
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Molecular Formula | C20H17FO2S |
CAS No. | 49627-27-2 |
Protocol | In Vitro | Treatment with 100 μM of Sulindac sulfide (SSide) causes cell death presumably by inducing apoptosis, resulting in marked decrease in Aβgeneration as well as in total protein expression. The IC50 value for Aβ42 secretion of Sulindac sulfide is 30.6±2.8 μM. SSone and naproxen have no effect either on Aβ40 or Aβ42 secretion as well as on Notch cleavage up to 100 μM. It is observed that an inhibition of γ42-secretase activity by Sulindac sulfide in a dose-dependent manner. The IC50 value of SSide for inhibiting γ42-secretase activity in vitro is 20.2±2.6 μM. A decrease is found in slope by the increase of the concentration of SSide in the plot of rate against the enzyme concentration, suggesting that Sulindac sulfide is not an irreversible or pseudo-irreversible inhibitor. Moreover, when the dialyzed solubilizedγ-secretase fraction is pretreated with Sulindac sulfide against CHAPSO buffer without Sulindac sulfide, γ-secretase activity is almost totally recovered. From these data, it is strongly suggested that the genuine molecular target of Sulindac sulfide is the γ-secretase complex and that Sulindac sulfide works as a reversible γ-secretase inhibitor |
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These protocols are for reference only. InvivoChem does not
independently validate these methods.
Solvent volume to be added | Mass (the weight of a compound) | |||
---|---|---|---|---|
Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 2.9376 mL | 14.6882 mL | 29.3763 mL | 58.7527 mL |
5mM | 0.5875 mL | 2.9376 mL | 5.8753 mL | 11.7505 mL |
10mM | 0.2938 mL | 1.4688 mL | 2.9376 mL | 5.8753 mL |
20mM | 0.1469 mL | 0.7344 mL | 1.4688 mL | 2.9376 mL |
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