Sulindac Sulfide (cis-Sulindac sulfide), a major metabolite of sulindac which is is a nonsteroidal anti-inflammatory drug (NSAID), is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.

BMS 299897 is a novel and potent sulfonamide γ-secretase inhibitor with an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).

Compound E (ɣ-secretase inhibitor XXI) is a novel, potent, cell-permeable, and selective inhibitor of γ-secretase with potential anti-AD (Alzheimer’s disease) effects.