STAT5-IN-1
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $900 | Check With Us |
| 500mg | $1500 | Check With Us |
| 1g | $2250 | Check With Us |
: Cat #: V3230 CAS #: 285986-31-4 Purity ≥ 98%
Description: STAT5-IN-1 (also known as STAT5 Inhibitor) is a STAT5 (signal transducer and activator of transcription 5) inhibitor with anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 293.28 |
|---|---|
| Molecular Formula | C16H11N3O3 |
| CAS No. | 285986-31-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 20 mg/mLr |
| Water: <1mg/mLr | |
| Ethanol: <1mg/mL | |
| SMILES Code | O=C(N/N=C/C1=COC2=C(C=CC=C2)C1=O)C3=CN=CC=C3 |
| Synonyms | STAT5 Inhibitor; STAT5-Inhibitor; STAT5-IN-1 |
| Protocol | In Vitro | The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 µM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4097 mL | 17.0486 mL | 34.0971 mL | 68.1942 mL |
| 5mM | 0.6819 mL | 3.4097 mL | 6.8194 mL | 13.6388 mL |
| 10mM | 0.3410 mL | 1.7049 mL | 3.4097 mL | 6.8194 mL |
| 20mM | 0.1705 mL | 0.8524 mL | 1.7049 mL | 3.4097 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.