STAT5-IN-1 (also known as STAT5 Inhibitor) is a STAT5 (signal transducer and activator of transcription 5) inhibitor with anticancer activity.

Golotimod (Orilotimod, SCV-07), is a potent and orally bioavailable synthetic peptide with an immunomodulating and antimicrobial activities.

Artesunate (Amivas; SM-804; WR-256283; HSDB-7458; Armax 200), an approved antimalaria agent, is a semisynthetic derivative of artemisinin with an IC50 of < 5 μM for small cell lung carcinoma cell line H69.

Narciclasine is a toxic plant growth modulator found in various Amaryllidaceae species.

RO8191 (RO-8191; CDM-3008) is a novel and potent activator of JAK/STAT pathway and interferon α receptor type 2 (IFNAR2) with antiviral effects.

Homoharringtonine (Omacetaxine mepesuccinate and HHT; trade name Synribo) is a naturally occurring and cytotoxic pharmaceutical substance that is indicated for treatment of chronic myeloid leukemia (CML).

STA-21 (NSC628869; Ochromycinone; STA21; Rac-STA-21) is a potent STAT3 inhibitor and natural antibiotic with anticancer and antimicrobial activity.

Cucurbitacin I, a naturally occurring triterpene analog, is a novel, potent and selective inhibitor of JAK2/STAT3 with potent anti-cancer activity on a variety of cancer cell types. autophagy and apoptosis were induced by cucurbitacin I.

BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor, which binds Stat3 with an affinity Kd of 504 nM.

AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM.