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SP-23

This product is for research use only, not for human use. We do not sell to patients.

SP-23
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$2775Check With Us
200mg$4160Check With Us
500mg$7020Check With Us
email: [email protected]        [email protected]

Cat #: V41902 CAS #: 2762552-74-7 Purity ≥ 98%

Description: SP-23 (SP23) is a novel, first-in-class and potent STING-targeting PROTAC degrader based on C-170 (STING inhibitor) with anti-inflammatory effects.

References: Liu J, et al. Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy. J Med Chem. 2022 May 12;65(9):6593-6611.

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Molecular Weight (MW)699.67
Molecular FormulaC34H33N7O10
CAS No.2762552-74-7
SMILES CodeO=C(CC1)NC(C1N(C2=O)C(C3=C2C=CC=C3NCCCCCCNC(/C=C/C(NC4=CC=C(NC(C5=CC=C([N+]([O-])=O)O5)=O)C=C4)=O)=O)=O)=O
SynonymsSP-23; SP23; SP 23
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.4292 mL7.1462 mL14.2925 mL28.5849 mL
5mM0.2858 mL1.4292 mL2.8585 mL5.7170 mL
10mM0.1429 mL0.7146 mL1.4292 mL2.8585 mL
20mM0.0715 mL0.3573 mL0.7146 mL1.4292 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.