STING agonist-4 (diABZI STING agonist-2) is a novel and potent agonist of stimulator of Interferon Genes (STING) receptor with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function. It dose-dependentally induced phosphorylation of IRF3 […]

STING agonist-3, compound 3, is a selective and non-nucleotide small-molecule STING agonist, which has durable anti-tumor effect and tremendous potential to improve treatment of cancer.

diABZI STING agonist-1 is a novel, potent and selective STING (stimulator of interferon genes) receptor agonist, with an EC50s of 130 nM for human PBMCs.

2′,3′-cGAMP (2′-3′-cyclic GMP-AMP) is an endogenous cGAMP molecule found in mammalian cells, it binds to STING with high affinity and is a potent inducer of interferon-β (IFNβ).

m-Cl-CCP [555-60-2] is a protonophore (h+ ionophore) and uncoupler of oxidative phosphorylation in mitochondria, inhibiting secretion of hepatic lipase and partially inhibiting the ph gradient-activated cl- uptake and cl-/cl- exchange activities in brush-border membrane vesicles.

SR-717 lithium is a novel, potent and non-nucleotide STING (stimulator of interferon genes) agonist with anticancer activities.

STING inhbitor 2 ( SN-011; SN011) is a novel and potent inhibitor of STING with potential anti-inflammatory activity.

ChX710 is a biochemical that can prime the type I interferon response to cytosolic DNA, thus inducing the ISRE promoter sequence, specific cellular Interferon-Stimulated Genes (ISGs), and the phosphorylation of Interferon Regulatory Factor (IRF) 3.

Cridanimod (XBIO-101; XBIO101; Virexxa) is a novel and potent immunomodulator and interferon inducer with antineoplastic activity.

ADU-S100 ammonium salt (ADUS100; ML RR-S2 CDA; MIW815) is potent STING agonist with anticancer and immunomodulatory activities.