SMAP-2
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2915 | To Be Confirmed |
| 200mg | $4370 | To Be Confirmed |
| 500mg | $7375 | To Be Confirmed |
: Cat #: V32196 CAS #: 1809068-70-9 Purity ≥ 99%
Description: SMAP-2 (DT-1154; SMAP 2; DT1154; SMAP2; DT 1154) is a novel, potent and orally bioavailable phosphatase 2A (PP2A) activator with potential anticancer activity. It inhibits the growth of KRAS-mutant lung cancers.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 532.57 |
|---|---|
| Molecular Formula | C27H27F3N2O4S |
| CAS No. | 1809068-70-9 |
| SMILES Code | O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[C@@H]2[C@@H](O)[C@H](N3C4=CC=CC=C4CCC5=CC=CC=C53)CCC2)=O |
| Synonyms | DT-1154; DT1154; DT 1154; SMAP-2; SMAP 2; |
| Protocol | In Vitro | SMAP-2 reduces cell viability of pancreatic ductal adenocarcinoma (PDA) cell lines in a dose-dependent manner. |
|---|---|---|
| In Vivo | SMAP-2 significantly reduces abdominal aortic aneurysms (AAA) incidence and aortic dilation in pro-AAA apolipoprotein E-null (ApoE-/-) mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8777 mL | 9.3884 mL | 18.7769 mL | 37.5537 mL |
| 5mM | 0.3755 mL | 1.8777 mL | 3.7554 mL | 7.5107 mL |
| 10mM | 0.1878 mL | 0.9388 mL | 1.8777 mL | 3.7554 mL |
| 20mM | 0.0939 mL | 0.4694 mL | 0.9388 mL | 1.8777 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.