SKF-86002
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1080 | Check With Us |
| 500mg | $1550 | Check With Us |
| 1g | $2325 | Check With Us |
: Cat #: V3025 CAS #: 72873-74-6 Purity ≥ 98%
Description: SKF-86002 is a novel and potent inhibitor of the p38 MAP kinase with IC50 of 0.5-1 uM; it inhibits LPS-induced IL-1 and TNF-α production in human monocytes with IC50 of 1 μM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 297.35 |
|---|---|
| Molecular Formula | C16H12FN3S |
| CAS No. | 72873-74-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | FC1=CC=C(C2=C(C3=CC=NC=C3)N4C(SCC4)=N2)C=C1 |
| Synonyms | SKF86002; SKF 86002; SKF-86002 |
| Protocol | In Vitro | SKF-86002 does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells. SKF-86002 (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV). |
|---|---|---|
| In Vivo | SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.3630 mL | 16.8152 mL | 33.6304 mL | 67.2608 mL |
| 5mM | 0.6726 mL | 3.3630 mL | 6.7261 mL | 13.4522 mL |
| 10mM | 0.3363 mL | 1.6815 mL | 3.3630 mL | 6.7261 mL |
| 20mM | 0.1682 mL | 0.8408 mL | 1.6815 mL | 3.3630 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.