SKF 82958

This product is for research use only, not for human use. We do not sell to patients.

SKF 82958
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1400To Be Confirmed.
500mg$2020To Be Confirmed.
1g$3030To Be Confirmed.

Cat #: V4977 CAS #: 74115-01-8 Purity ≥ 98%

Description: SKF-82958 HBr, the hydrobromide salt of SKF-81297, is a novel, potent and selective dopamine D1/D5 receptor full agonist which stimulates motor behaviour of MPTP-lesioned monkeys.

References: Haile CN, et al. The dopamine D(1) receptor agonist SKF-82958 serves as a discriminative stimulus in the rat. Eur J Pharmacol. 2000;388(2):125-131.

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Molecular Weight (MW)410.73
Molecular FormulaC19H21BrClNO2
CAS No.74115-01-8
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
ProtocolIn VivoSKF-82958 ((±)-SKF 82958) hydrobromide (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 hydrobromide training dose 0.03 mg/kg. Increasing the dose of SKF-82958 hydrobromide also results in a significant reduction in response rate
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.4347 mL12.1734 mL24.3469 mL48.6938 mL
5mM0.4869 mL2.4347 mL4.8694 mL9.7388 mL
10mM0.2435 mL1.2173 mL2.4347 mL4.8694 mL
20mM0.1217 mL0.6087 mL1.2173 mL2.4347 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.